1-(Thiazol-2-yl)piperazine → HCID 54520201, compound

HRID 1282191Notes

Reaction equation

HRID 1282191 reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[N:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1.Cl[CH:13]([C:15]1[CH:20]=[CH:19][C:18]([CH2:21][NH:22][C:23](=[O:25])[CH3:24])=[CH:17][CH:16]=1)[CH3:14]>>[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[N:6]1[CH2:7][CH2:8][N:9]([CH:13]([C:15]2[CH:20]=[CH:19][C:18]([CH2:21][NH:22][C:23](=[O:25])[CH3:24])=[CH:17][CH:16]=2)[CH3:14])[CH2:10][CH2:11]1

Participants

3

Reactant 2

HCID 9118061-(Thiazol-2-yl)piperazineHCID 18423036N-(4-(1-chloroethyl)phenylmethyl)acetamide

Product 1

HCID 54520201HCID 54520201, compound

Procedure

By similar reaction and treatment to that in Example 1(5) using 1-(2-thiazolyl)piperazine instead of phenylpiperazine and N-(4-(1-chloroethyl)phenylmethyl)acetamide instead of N-(4-chloromethylphenylmethyl) acetamide, the title compound was obtained as a brown oil.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-998262b40c5644dbb7449d54bbe42536
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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