1-(6-fluoropyridin-2-yl)piperazine → HCID 11537933, compound

HRID 1282193Notes

Reaction equation

HRID 1282193 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([NH:12][C:13](=[O:15])[CH3:14])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[F:16][C:17]1[N:22]=[C:21]([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)[CH:20]=[CH:19][CH:18]=1>>[F:16][C:17]1[N:22]=[C:21]([N:23]2[CH2:28][CH2:27][N:26]([CH2:2][C:3]3[CH:8]=[CH:7][C:6]([C:9]4([NH:12][C:13](=[O:15])[CH3:14])[CH2:11][CH2:10]4)=[CH:5][CH:4]=3)[CH2:25][CH2:24]2)[CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 37288181-(6-fluoropyridin-2-yl)piperazineHCID 18423039N-(1-(4-chloromethylphenyl)cyclopropyl)acetamide

Product 1

HCID 11537933HCID 11537933, compound

Procedure

By similar reaction and treatment to that in Example 1(5) using N-(1-(4-chloromethylphenyl)cyclopropyl)acetamide obtained in Example 71(1) instead of N-(4-chloromethylphenylmethyl)acetamide and 1-(6-fluoropyridin-2-yl)piperazine obtained in Example 85(2) instead of phenylpiperazine, the title compound was obtained as white crystals, m.p.=135-136° C.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-e6a5ea0a32324c2dad9eaa0175c3fb70
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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