1-(4-Fluorophenyl)piperazine dihydrochloride → (S)-N-(1-(4-((4-(4-fluorophenyl)piperazin-1-yl)methyl)phenyl)ethyl)acetamide

Participants

Role	Name	HCID	Charge
Reactant	1-(4-Fluorophenyl)piperazine dihydrochloride	HCID 16211916	—
Reactant	(S)-N-(1-(4-(Chloromethyl)phenyl)ethyl)acetamide	HCID 53659736	—
Product	(S)-N-(1-(4-((4-(4-fluorophenyl)piperazin-1-yl)methyl)phenyl)ethyl)acetamide	HCID 11696105	—

Reaction Steps

By similar reaction and treatment to that in Example 1(5) using (S)-N-(1-(4-chloromethylphenyl)ethyl)acetamide instead of N-(4-chloromethylphenylmethyl)acetamide and 1-(4-fluorophenyl)piperazine dihydrochloride instead of phenylpiperazine, the title compound was obtained as white crystals, m.p.=114-115° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06455528B1
Source dataset	uspto-grants-2002_09
ORD ID	ord-7e1de508a2a746ec9852e5302d1756cd
Source note	uspto-grants-2002_09