1-(4-Fluorophenyl)piperazine dihydrochloride → HCID 11515925, compound

HRID 1282199Notes

Reaction equation

HRID 1282199 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C@H:9]([NH:11][C:12](=[O:14])[CH3:13])[CH3:10])=[CH:5][CH:4]=1.Cl.Cl.[F:17][C:18]1[CH:23]=[CH:22][C:21]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)=[CH:20][CH:19]=1>>[F:17][C:18]1[CH:19]=[CH:20][C:21]([N:24]2[CH2:29][CH2:28][N:27]([CH2:2][C:3]3[CH:8]=[CH:7][C:6]([C@H:9]([NH:11][C:12](=[O:14])[CH3:13])[CH3:10])=[CH:5][CH:4]=3)[CH2:26][CH2:25]2)=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 162119161-(4-Fluorophenyl)piperazine dihydrochlorideHCID 53659735HCID 53659735, compound

Product 1

HCID 11515925HCID 11515925, compound

Procedure

By similar reaction and treatment to that in Example 1(5) using (R)-N-(1-(4-chloromethylphenyl)ethyl)acetamide instead of N-(4-chloromethylphenylmethyl)acetamide and 1-(4-fluorophenyl)piperazine dihydrochloride instead of phenylpiperazine, the title compound was obtained as white crystals, m.p.=114-115° C.

Workup

  1. customBy similar reaction and treatment to that in Example

Sources & evidence

ORD record
ord-5e79a9ff74324a59b18f8b3a09515fc4
Source dataset
uspto-grants-2002_09
Patent number
US06455528B1

Reaction notes

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