5-Chloro-2-methylphenyl isothiocyanate → HCID 10110540, compound

HRID 1282205Notes

Reaction equation

HRID 1282205 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([N:8]=[C:9]=[S:10])[CH:7]=1.[NH2:12][C:13]1[S:14][C:15]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:19]=[CH:18][C:16]=2[N:17]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([NH:8][C:9]([NH:12][C:13]2[S:14][C:15]3[C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[CH:19]=[CH:18][C:16]=3[N:17]=2)=[S:10])[CH:7]=1

Participants

3

Reactant 2

HCID 295195-Chloro-2-methylphenyl isothiocyanateHCID 838513Naphtho[2,1-d]thiazol-2-ylamine

Product 1

HCID 10110540HCID 10110540, compoundYield 21.9%

Procedure

Prepared using Method A from 5.0 g (27.2 mmol) of 5-chloro-2-methyl-phenyl isothiocyanate and 5.0 g (25 mmol) of 2-amino-naptho[2,1-d]thiazole to give 2.1 g of title compound as an off-white solid, (21% yield).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-0ad07b0123104979860fcc4e7e18e350
Source dataset
uspto-grants-2002_09
Patent number
US06455566B1

Reaction notes

Loading…