HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-6-isothiocyanatotoluene → 1-(4-Chloro-2-methyl-phenyl)-3-(4-methyl-oxazol-2-yl)-thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-6-isothiocyanatotoluene | HCID 90021 | — |
| Reactant | 4-Methyloxazol-2-amine | HCID 535824 | — |
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-(4-Chloro-2-methyl-phenyl)-3-(4-methyl-oxazol-2-yl)-thiourea | HCID 9921816 | — |
Reaction Steps
Prepared using Method A from 4.04 g (22 mmol) of 4-chloro-2-methyl-phenyl isothiocyanate and 2.16 g (22 mmol) of 2-amino-4-methyloxazole to give 4.5 g of crude title compound. Pure title compound was obtained by flash chromatography (silica Merck 60, CH2Cl2-CH3OH, 19:1) and crystallization from CH3CN to give 2.12 g of the title compound as a yellow solid (72.5% yield, m.p. 214° C. with decomposition).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06455566B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-9a3ed50891ed4f648911b597fea85cdc |
| Source note | uspto-grants-2002_09 |