5-Chloro-2-methylphenyl isothiocyanate → 3-(5-Chloro-2-methyl-phenyl)-1-ethyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-thiourea

Participants

Role	Name	HCID	Charge
Reactant	5-Chloro-2-methylphenyl isothiocyanate	HCID 29519	—
Reactant	N-Ethyl-1,3,5-trimethyl-1H-pyrazol-4-amine	HCID 22335539	—
Product	3-(5-Chloro-2-methyl-phenyl)-1-ethyl-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)-thiourea	HCID 10131886	70%

Reaction Steps

Prepared using Method A from 9.33 g (51 mmol) of 5-chloro-2-methyl-phenyl isothiocyanate and 4-ethylamino-1,3,5-trimethylpyrazole (7.2 g, 47 mmol) of step B to give 5.4 g of title compound as a white solid (70% yield, m.p. 144-145° C.).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06455566B1
Source dataset	uspto-grants-2002_09
ORD ID	ord-4438d82d6f7f436b843226fc5b54365d
Source note	uspto-grants-2002_09