HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 7-Benzyloxy-6-methoxy-3,4-dihydro-2H-naphthalen-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 7-Hydroxy-6-methoxy-1-tetralone | HCID 316840 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 7-Benzyloxy-6-methoxy-3,4-dihydro-2H-naphthalen-1-one | HCID 21862716 | 62.8% |
Reaction Steps
A mixture of 4.5 g (0.0233 mole) of 7-hydroxy-6-methoxy-1-tetralone, 5.4 g (0.032 mole) of benzyl bromide and 10 g (0.072 mole) of K2CO3 in 150 ml of acetone was heated to reflux overnight. The reaction as cooled, poured into water and extracted with EtOAc. The EtOAc was dried over Na2SO4 and evaporated to give 7 g of crude product. Crystallization with Et2O gave 4.13 g of product as a white solid, mp 110-111° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06455572B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-33151e0b0c7f4f529582ec4a79c81cd7 |
| Source note | uspto-grants-2002_09 |