反应详情

A mixture of 10 g (0.027 mole) of 2-cyano-2-(4-phenylthiophenyl)hexyl bromide and 8 g (0.13 mole) of imidazole is heated with stirring at 160° for four hours. The reaction mixture is poured into water and extracted with ether. The combined ether extracts are washed with water and dried over Na2SO4. The drying agent is filtered and to the filtrate is bubbled dry hydrogen chloride gas until solution is strongly acidic. The hydrochloride salt is washed with ether and back neutralized with dilute ammonium hydroxide solution to give 8 g of pure product.

1. temperatureis heated
2. extractionextracted with ether
3. washThe combined ether extracts are washed with water
4. dry with materialdried over Na2SO4
5. filtrationThe drying agent is filtered and to the filtrate
6. customis bubbled dry hydrogen chloride gas until solution
7. washThe hydrochloride salt is washed with ether