Benzoic Acid → HCID 69969435, compound

Participants

Reaction Steps

Employing the same general procedure as for the preparation of 4-tert-butyl-3-(4′-trifluoromethyl)phenoxy]benzoic acid (Compound P), 1.02 g (3.2 mmol) of 5-bromo-2-tert-butyl-1-[(4′-methyl)phenoxy]benzene (Compound J) was converted into the title compound using 4.7 mL (8.0 mmol) of tert-butyllithium solution (1.7M in pentane) and 10 mL of tetrahydrofuran. Purification by flash chromatography (silica, 3% methanol in chloroform) gave the title compound as a creme solid.

Provenance & Evidence