ethyl 5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acetate → HCID 18424279, compound

HRID 1282372Notes

Reaction equation

HRID 1282372 reaction equation
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:23]=[CH:22][C:6]([C:7]([C:9]2[N:13]([CH3:14])[C:12]([CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:11][C:10]=2[CH3:21])=[O:8])=[CH:5][CH:4]=1.Cl[C:27]1C=CC(C(C2N(C)C(CC(OCC)=O)=CC=2C)=O)=CC=1>>[F:25][C:2]([F:1])([F:24])[C:3]1[CH:4]=[CH:5][C:6]([C:7]([C:9]2[N:13]([CH3:14])[C:12]([CH:15]([CH3:27])[C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:11][C:10]=2[CH3:21])=[O:8])=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 118463ethyl 5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acetateHCID 18424201HCID 18424201, compound

Product 1

HCID 18424279HCID 18424279, compound

Procedure

The methylation procedure of Example 77A is repeated, except that an equivalent quantity of ethyl 5-(p-trifluoromethylbenzoyl)-1,4-dimethylpyrrole-2-acetate (from Example 89) is methylated instead of the ethyl 5-(p-chlorobenzoyl)-1,4-dimethylpyrrole-2-acetate used in Example 77A, to yield ethyl 5-(p-trifluoromethylbenzoyl)-1,4,α-trimethylpyrrole-2-acetate.

Sources & evidence

ORD record
ord-0d1bb286fab44fdabaf495ebbf46f986
Source dataset
uspto-grants-2002_09
Patent number
US06455703B2

Reaction notes

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