ethyl 5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acetate → HCID 18424188, compound

HRID 1282373Notes

Reaction equation

HRID 1282373 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:21]=[CH:22][C:23]=1[O:24][CH3:25])[C:6]([C:8]1[N:12]([CH3:13])[C:11]([CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:10][C:9]=1[CH3:20])=[O:7].Cl[C:27]1C=CC(C(C2N(C)C(CC(OCC)=O)=CC=2C)=O)=CC=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:21]=[CH:22][C:23]=1[O:24][CH3:25])[C:6]([C:8]1[N:12]([CH3:13])[C:11]([CH:14]([CH3:27])[C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:10][C:9]=1[CH3:20])=[O:7]

Participants

3

Reactant 2

HCID 118463ethyl 5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acetateHCID 18424209HCID 18424209, compound

Product 1

HCID 18424188HCID 18424188, compound

Procedure

The methylation procedure of Example 77A is repeated, except that an equivalent quantity of ethyl 5-(3′,4′-dimethoxybenzoyl)-1,4-dimethylpyrrole-2-acetate (from Example 90) is methylated instead of the ethyl 5-(p-chlorobenzoyl)-1,4-dimethylpyrrole-2-acetate used in Example 77A, to yield ethyl 5-(3′,4′-dimethoxybenzoyl)-1,4,α-trimethylpyrrole-2-acetate.

Sources & evidence

ORD record
ord-f81387a6192e4092b4ee18b4bfda59ad
Source dataset
uspto-grants-2002_09
Patent number
US06455703B2

Reaction notes

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