ethyl 5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acetate → HCID 18424257, compound

HRID 1282374Notes

Reaction equation

HRID 1282374 reaction equation
[Br:1][C:2]1[C:22]([Br:23])=[CH:21][C:20]([Br:24])=[CH:19][C:3]=1[C:4]([C:6]1[N:10]([CH3:11])[C:9]([CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:8][C:7]=1[CH3:18])=[O:5].Cl[C:26]1C=CC(C(C2N(C)C(CC(OCC)=O)=CC=2C)=O)=CC=1>>[Br:1][C:2]1[C:22]([Br:23])=[CH:21][C:20]([Br:24])=[CH:19][C:3]=1[C:4]([C:6]1[N:10]([CH3:11])[C:9]([CH:12]([CH3:26])[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:8][C:7]=1[CH3:18])=[O:5]

Participants

3

Reactant 2

HCID 118463ethyl 5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acetateHCID 18424339HCID 18424339, compound

Product 1

HCID 18424257HCID 18424257, compound

Procedure

The methylation procedure of Example 77A is repeated, except that an equivalent quantity of ethyl 5-(2′,3′,5′-tribromobenzoyl)-1,4-dimethylpyrrole-2-acetate (from Example 91) is methylated instead of the ethyl 5-(p-chlorobenzoyl)-1,4-dimethylpyrrole-2-acetate used in Example 77A, to yield ethyl 5-(2′,3′,5′-tribromobenzoyl)-1,4,α-trimethylpyrrole-2-acetate.

Sources & evidence

ORD record
ord-9ef189ee7f2843edbc8fe6c276b5e6fc
Source dataset
uspto-grants-2002_09
Patent number
US06455703B2

Reaction notes

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