Sulfuric Acid → HCID 69978127, compound

Participants

Reaction Steps

At 0C, a solution of 0.52 g of sodium nitrite in 1 ml of water is added within a period of 30 minutes to a mixture of 1 g of 2-amino-4-fluorobenzoic acid, 15 ml of water and 6.24 ml of concentrated sulfuric acid. The mixture is then stirred for one hour. Following addition of 0.3 g of amidosulfonic acid, 0.7 g of methyl acrylate in 9 ml of isopropanol are added dropwise, and 10 mg of palladium acetylacetonate are added. After 4 hours at 40° C., 30 ml of water are added and the resulting precipitate is filtered off. Drying gives 1.1 g of 4-fluoro-2-(3-methoxy-3-oxo-1-propenyl)-benzoic acid of melting point 151-153° C.

Provenance & Evidence