HCID 69977092, compound → HCID 18424530, compound

Participants

Reaction Steps

Without addition of an additional hydrogenation catalyst, 43 g of 4-chloro-2-(3-hydroxy-3-oxo-1-propenyl)-benzoic acid in the form of the isolated solid from Example 5 in 400 ml of methanol are hydrogenated at 40° C. and a hydrogen pressure of from 20 to 40 bar. Filtration through Celite® and removal of the solvents under reduced pressure gives 35.3 g of product which, according to gas chromatography, contains 81 % of 4-chloro-2-(3-methoxy-3-oxo-1-propenyl)-benzoic acid. The same product is obtained using, instead of 4-chloro-2-(3-hydroxy-3-oxo-1-propenyl)-benzoic acid, 4-chloro-2-(3-methoxy-3-oxo-1-propenyl)-benzoic acid.

Provenance & Evidence