Hydrochloric Acid → HCID 9866244, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-bromo-6-pentafluoroethyl-2,2-bis(fluoromethyl)-2H-1-benzopyran (0.40 g), bis(triphenylphosphine)palladium chloride (28 mg), 2-cyanoethylamine (0.28 g), potassium iodide (0.17 g) and N,N-dimethylformamide (5 ml) was stirred under a CO atmosphere at 80° C. for 2 hours. To the reaction mixture, 2N HCl was added, followed by extraction with ethyl acetate; the extract was dried with sodium sulfate and subjected to silica gel column chromatography (eluent; hexane/ethyl acetate=1/1) to give the titled compound (0.33 g) having a melting point of 144-145° C.

Provenance & Evidence