Sodium Hydroxide → HCID 23469007, compound

Participants

Reaction Steps

A solution of sodium hydroxide (0.20 g) in water (20 ml) was added to a solution of 1-(4-carbethoxybenzyl)-2-(imidazol-1-ylmethyl) pyrrole (1.55 g) in ethanol (20 ml) and the mixture was heated under reflux for 8 hours. The solution was evaporated and the residue was taken up in water (25 ml). The solution was acidified with acetic acid and continuously extracted with chloroform to give a solid which was crystallised from isopropanol to give 1-(4-carboxybenzyl)-2-(imidazol-1-ylmethyl)pyrrole (0.50 g), m.p. 190°-191° (d).

Provenance & Evidence