反应详情

An amount (0.28 g) of methyl 5-fluoro-4-fluoromethyl-4-(4-trifluoromethylphenoxy)-2-pentynoate was added dropwise to o-dichlorobenzene (1.0 ml) during refluxing under a nitrogen atmosphere. After the end of the dropwise addition, the reaction mixture was refluxed for 3 hours. The solvent was distilled off under reduced pressure and the resulting residue was subjected to silica gel column chromatography (eluent; 10% tetrahydrofuran/hexane) to give the titled compound (0.25 g).

1. temperatureduring refluxing under a nitrogen atmosphere
2. additionAfter the end of the dropwise addition
3. temperaturethe reaction mixture was refluxed for 3 hours
4. distillationThe solvent was distilled off under reduced pressure