Diazomethane → HCID 3013763, compound

HRID 1282513Notes

Reaction equation

HRID 1282513 reaction equation
[CH2:1]([N:5]([S:32]([C:35]1[CH:40]=[CH:39][C:38]([CH3:41])=[CH:37][CH:36]=1)(=[O:34])=[O:33])[C@H:6]([C:29]([OH:31])=[O:30])[CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]([O:14][CH2:15][CH:16]1[C:28]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[C:22]2[C:17]1=[CH:18][CH:19]=[CH:20][CH:21]=2)=[O:13])[CH:2]([CH3:4])[CH3:3].[N+](=[CH2:44])=[N-]>>[CH3:44][O:30][C:29](=[O:31])[C@H:6]([CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]([O:14][CH2:15][CH:16]1[C:28]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[C:22]2[C:17]1=[CH:18][CH:19]=[CH:20][CH:21]=2)=[O:13])[N:5]([CH2:1][CH:2]([CH3:3])[CH3:4])[S:32]([C:35]1[CH:36]=[CH:37][C:38]([CH3:41])=[CH:39][CH:40]=1)(=[O:33])=[O:34]

Participants

3

Reactant 2

HCID 9550DiazomethaneHCID 3013742(2S)-6-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[isobutyl(p-tolylsulfonyl)amino]hexanoic acid

Product 1

HCID 3013763HCID 3013763, compoundYield 68%

Procedure

The product from example 45 was treated with excess diazomethane, yielding the title compound in 68% yield.

Sources & evidence

ORD record
ord-bb180b87ab93406f9427fbcea900a485
Source dataset
uspto-grants-2002_09
Patent number
US06455587B1

Reaction notes

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