4-Fluorobenzyl bromide → HCID 86604363, compound

HRID 1282534Notes

Reaction equation

HRID 1282534 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C@H:12]([C:28]([OH:30])=[O:29])[CH2:13][CH2:14][CH2:15][CH2:16][NH:17][S:18]([C:21]2[CH:26]=[CH:25][C:24]([Br:27])=[CH:23][CH:22]=2)(=[O:20])=[O:19])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[F:31][C:32]1[CH:39]=[CH:38][C:35]([CH2:36]Br)=[CH:34][CH:33]=1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C@H:12]([C:28]([OH:30])=[O:29])[CH2:13][CH2:14][CH2:15][CH2:16][N:17]([S:18]([C:21]2[CH:22]=[CH:23][C:24]([Br:27])=[CH:25][CH:26]=2)(=[O:20])=[O:19])[CH2:36][C:35]2[CH:38]=[CH:39][C:32]([F:31])=[CH:33][CH:34]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 680214-Fluorobenzyl bromideHCID 86604364HCID 86604364, compound

Product 1

HCID 86604363HCID 86604363, compoundYield 85%

Procedure

Nα,Nε-di-(4-bromobenzenesulfonyl)-L-lysine was reacted with 4-fluorobenzyl bromide under the conditions described in example 127 to yield 85% of the desired product.

Sources & evidence

ORD record
ord-5e2c772c8ba14fdbb72de83dfca2b8bb
Source dataset
uspto-grants-2002_09
Patent number
US06455587B1

Reaction notes

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