2-Amino-4,5-dimethyl-1,3-thiazole → 2H-(1)Benzothieno(2,3-e)-1,2-thiazine-3-carboxamide, N-(4,5-dimethyl-2-thiazolyl)-4-hydroxy-2-methyl-, 1,1-dioxide

HRID 128267Notes

Reaction equation

HRID 128267 reaction equation
[OH:1][C:2]1[C:7]2[S:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[C:6]=2[S:5](=[O:16])(=[O:15])[N:4]([CH3:17])[C:3]=1[C:18](OC)=[O:19].[CH3:22][C:23]1[N:24]=[C:25]([NH2:29])[S:26][C:27]=1[CH3:28]>>[CH3:22][C:23]1[N:24]=[C:25]([NH:29][C:18]([C:3]2[N:4]([CH3:17])[S:5](=[O:16])(=[O:15])[C:6]3[C:10]4[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=4[S:8][C:7]=3[C:2]=2[OH:1])=[O:19])[S:26][C:27]=1[CH3:28]

Participants

3

Reactant 2

HCID 732382-Amino-4,5-dimethyl-1,3-thiazoleHCID 547072593-carbomethoxy-4-hydroxy-2-methyl-2H-[1]benzothieno[2,3-e]-1,2-thiazine 1,1-dioxide

Product 1

HCID 546976422H-(1)Benzothieno(2,3-e)-1,2-thiazine-3-carboxamide, N-(4,5-dimethyl-2-thiazolyl)-4-hydroxy-2-methyl-, 1,1-dioxideYield 56%

Procedure

Prepared analogous to Example 1 from methyl 4-hydroxy-2-methyl-2H-[1]-benzothieno[2,3-e]-1,2-thiazine-3-carboxylate-1,1-dioxide and 4,5-dimethyl-2-thiazolamine with a yield of 56% of theory.

Sources & evidence

ORD record
ord-c3ed6dc57ee64d65bbf34be13872c949
Source dataset
uspto-grants-1981_03
Patent number
US04259336

Reaction notes

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