5-Propyl-1,3-thiazol-2-amine → 4-Hydroxy-2-methyl-N-(5-propyl-2-thiazolyl)-2H-[1] benzothieno [2,3-e]-1,2-thiazine-3-carboxamide-1,1-dioxide

HRID 128268Notes

Reaction equation

HRID 128268 reaction equation
[OH:1][C:2]1[C:7]2[S:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[C:6]=2[S:5](=[O:16])(=[O:15])[N:4]([CH3:17])[C:3]=1[C:18](OC)=[O:19].[CH2:22]([C:25]1[S:29][C:28]([NH2:30])=[N:27][CH:26]=1)[CH2:23][CH3:24]>>[OH:1][C:2]1[C:7]2[S:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[C:6]=2[S:5](=[O:16])(=[O:15])[N:4]([CH3:17])[C:3]=1[C:18]([NH:30][C:28]1[S:29][C:25]([CH2:22][CH2:23][CH3:24])=[CH:26][N:27]=1)=[O:19]

Participants

3

Reactant 2

HCID 32822365-Propyl-1,3-thiazol-2-amineHCID 547072593-carbomethoxy-4-hydroxy-2-methyl-2H-[1]benzothieno[2,3-e]-1,2-thiazine 1,1-dioxide

Product 1

HCID 867376354-Hydroxy-2-methyl-N-(5-propyl-2-thiazolyl)-2H-[1] benzothieno [2,3-e]-1,2-thiazine-3-carboxamide-1,1-dioxideYield 37%

Procedure

Prepared analogous to Example 1 from methyl 4-hydroxy-2-methyl-2H-[1] benzothieno [2,3-e]-1,2-thiazine-3-carboxylate-1,1-dioxide and 5-propyl-2-thiazolamine with a yield of 37% of theory.

Sources & evidence

ORD record
ord-c83dd7ffc75a4534bb16622d31f0fbd7
Source dataset
uspto-grants-1981_03
Patent number
US04259336

Reaction notes

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