Benzenesulfonyl chloride → HCID 178478681, compound

HRID 1282702Notes

Reaction equation

HRID 1282702 reaction equation
[ClH:1].Cl.Cl.N1C=C(CN2C3C=CC(C4C=NC=CC=4)=CC=3CN(C(=O)C(F)(F)F)C(CC3C=CC=CC=3)C2)N=C1.Cl.N1C=C(CN2C3C=CC(C#N)=CC=3CN(S(C)(=O)=O)[C@H](CC3C=CC=CC=3)C2)N=C1.[C:71]1([S:77]([Cl:80])(=[O:79])=[O:78])[CH:76]=[CH:75][CH:74]=[CH:73][CH:72]=1.Cl.Cl.Cl.Cl.[C:85]([C:87]1[CH:88]=[CH:89][C:90]2[N:96]([CH2:97][C:98]3[N:99]=[CH:100][NH:101][CH:102]=3)[CH2:95][C@@H:94]([CH2:103][C:104]3[CH:105]=[N:106][CH:107]=[CH:108][CH:109]=3)[N:93](S(C)(=O)=O)[CH2:92][C:91]=2[CH:114]=1)#[N:86]>>[ClH:80].[ClH:1].[C:85]([C:87]1[CH:88]=[CH:89][C:90]2[N:96]([CH2:97][C:98]3[N:99]=[CH:100][NH:101][CH:102]=3)[CH2:95][C@@H:94]([CH2:103][C:104]3[CH:105]=[N:106][CH:107]=[CH:108][CH:109]=3)[N:93]([S:77]([C:71]3[CH:76]=[CH:75][CH:74]=[CH:73][CH:72]=3)(=[O:79])=[O:78])[CH2:92][C:91]=2[CH:114]=1)#[N:86]

Participants

5

Reactant 4

HCID 7369Benzenesulfonyl chlorideHCID 178478619HCID 178478619, compoundHCID 178504922HCID 178504922, compoundHCID 178504923HCID 178504923, compound

Product 1

HCID 178478681HCID 178478681, compoundYield 2%

Procedure

Example 375 was prepared as a solid in 2% yield from Compound B of Example 350 as described for Compound C of Example 350 using benzenesulfonyl chloride, and Compound D of Example 350.

Sources & evidence

ORD record
ord-1dd687e9fc6b42ddb7a21f0e6c1394c3
Source dataset
uspto-grants-2002_09
Patent number
US06455523B1

Reaction notes

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