4-Nitrobenzenesulfonyl chloride → HCID 178509453, compound

HRID 1282704Notes

Reaction equation

HRID 1282704 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].Cl.[NH:15]1[CH:19]=[C:18]([CH2:20][N:21]2[C:27]3[CH:28]=[CH:29][C:30]([C:32]#[N:33])=[CH:31][C:26]=3[CH2:25][N:24](S(C)(=O)=O)[C@H:23]([CH2:38][C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=3)[CH2:22]2)[N:17]=[CH:16]1>>[C:32]([C:30]1[CH:29]=[CH:28][C:27]2[N:21]([CH2:20][C:18]3[N:17]=[CH:16][NH:15][CH:19]=3)[CH2:22][C@@H:23]([CH2:38][C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=3)[N:24]([S:10]([C:7]3[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=3)(=[O:12])=[O:11])[CH2:25][C:26]=2[CH:31]=1)#[N:33]

Participants

3

Reactant 2

HCID 74044-Nitrobenzenesulfonyl chlorideHCID 178504922HCID 178504922, compound2×

Product 1

HCID 178509453HCID 178509453, compoundYield 3%

Procedure

Example 383 was prepared as a white solid in 3% yield from 4-nitrobenzene sulfonylchloride and Compound C of Example 248 by the following sequence: Compound C of Example 350, except that the reaction was run at room temperature and no purification was performed; Compound C of Example 380.

Workup

  1. customwas run at room temperature
  2. customno purification

Sources & evidence

ORD record
ord-d349bc9b736446e0895e04203c7f623a
Source dataset
uspto-grants-2002_09
Patent number
US06455523B1

Reaction notes

Loading…