Ethanesulfonylchloride, 2-chloro- → HCID 69842640, compound

Participants

Reaction Steps

2-Chloroethanesulfonyl chloride (1.85 g, 11.4 mmol) was added to a solution of Compound C of Example 248 (1.0 g, 3.79 mmol) and DIEA (2.6 mL, 15.16 mmol) in dichloromethane (16 mL) at 0° C. under argon. After stirring for 16 hr, the reaction was diluted with chloroform (20 mL) and NaHCO3 (5 mL). The layers were separated, the aqueous layer was extracted with chloroform (2×50 mL). The combined organic extracts were washed with NaHCO3 (2×20 mL) and brine (2×50 mL), dried over MgSO4, filtered and concentrated, to afford Compound A (1.55 g, 116.5%).

Provenance & Evidence