Nipecotic Acid → Pipecolic Acid

HRID 1282715Notes

Reaction equation

HRID 1282715 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH:3]([C:7]([OH:9])=[O:8])[CH2:2]1.[C:10]([N:13]1[CH2:18][CH2:17][CH:16]([C:19]([OH:21])=[O:20])[CH2:15][CH2:14]1)(=[NH:12])[NH2:11]>>[NH:1]1[CH2:2][CH2:3][CH2:4][CH2:5][CH:6]1[C:19]([OH:21])=[O:20].[C:10]([N:13]1[CH2:14][CH2:15][CH2:16][CH2:17][CH:18]1[C:7]([OH:9])=[O:8])(=[NH:12])[NH2:11]

Participants

4

Reactant 2

HCID 4498Nipecotic AcidHCID 51523141-Carbamimidoylpiperidine-4-carboxylic acid

Product 2

HCID 849Pipecolic AcidHCID 12011843HCID 12011843, compound

Procedure

The above-named acylating agent is prepared from 3-piperidine carboxylic acid according to the procedure of Example XX for making 1-guanyl-4-piperidine carboxylic acid. Utilization of 2-piperidine carboxylic acid in place of the 4-isomer provides 1-guanyl-2-piperidine carboxylic acid.

Sources & evidence

ORD record
ord-82b06c8d46b14034baccd3f42929039a
Source dataset
uspto-grants-1976_08
Patent number
US03972872

Reaction notes

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