HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxylamine → Ciclopirox
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxylamine | HCID 787 | — |
| Reactant | 6-Cyclohexyl-4-methyl-2H-pyran-2-one | HCID 19858323 | — |
| Solvent | 2-Aminopyridine | HCID 10439 | — |
| Solvent | 2-Amino-6-methylpyridine | HCID 15765 | — |
| Product | Ciclopirox | HCID 2749 | 37% |
Reaction Steps
2 g of 4-methyl-6-cyclohexyl-2-pyrone and 1 g of hydroxylamine were dissolved in a mixture of 1.5 g of 2-aminopyridine and 4.5 g of 2-amino-6-methylpyridine and stored for 9 days at room temperature. After the usual working up, there were obtained 0.79 g (37 %) of 1-hydroxy-4-methyl-6-cyclohexyl-2-pyridone melting at 143° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03972888 |
| Source dataset | uspto-grants-1976_08 |
| ORD ID | ord-fcf4ae0ebc8d4a7cae5a15cda724183c |
| Source note | uspto-grants-1976_08 |