Imidazole → HCID 21520143, compound

Participants

Reaction Steps

1 g of 3,4-dimethyl-6-(2,4-dimethylbenzyl)-2-pyrone, 0.5 g of hydroxylamine hydrochloride and 3 g of imidazole were heated for 8 hours to 75° C and then worked up in the usual manner. There were obtained 0.63 g (59 %) of 1-hydroxy-3,4-dimethyl-6-(2,4-dimethylbenzyl)-2-pyridone melting at 141° C (Calc.: 5.4 % N; found: 5.6 % N). When using pyridine instead of imidazole under otherwise equal reaction conditions, the yield was 0.003 g (0.3 %).

Provenance & Evidence