HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → Ciclopirox
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Hydroxylamine, sulfate (1:1) | HCID 159255 | — |
| Reactant | 6-Cyclohexyl-4-methyl-2H-pyran-2-one | HCID 19858323 | — |
| Product | Ciclopirox | HCID 2749 | 93.3% |
Reaction Steps
20 g of 4-methyl-6-cyclohexyl-2-pyrone, 8 g of hydroxylamine sulfate and 50 g of imidazole were heated to 90° C. Further 10 g of hydroxylamine sulfate were added portionwise in the course of 3 hours. After a reaction time of 5 hours, the mixture was worked up. 11.8 g of 1-hydroxy-4-methyl-6-cyclohexyl-2-pyridone melting at 143° C were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03972888 |
| Source dataset | uspto-grants-1976_08 |
| ORD ID | ord-7e54ad5a19da48c1b0ac8ab433db7310 |
| Source note | uspto-grants-1976_08 |