Potassium Carbonate → HCID 20364077, compound

Participants

Reaction Steps

283 g (2 moles) of 4-chloro-2-methylphenol, 300 g of potassium carbonate and 2 g of potassium iodide were suspended in 2 l of anhydrous acetone and the suspension was heated to the boil. 359 g (2 moles) of bromopinacolone were then gradually added dropwise, while stirring, and the reaction mixture was heated for 5 hours under reflux. Thereafter, first the solvent, and then the ketone were distilled off under reduced pressure. 381 g (79% of theory) of 1-(2-methyl-4-chlorophenoxy)-3,3-dimethyl-butan-2-one of boiling point 109°-112°C/0.1 mm were obtained.

Provenance & Evidence