反应详情

50 g (0.42 mole) of thionyl chloride were slowly added dropwise at room temperature to a solution of 106 g (0.39 mole) of 1-hydroxy-2-(2-methyl-4-chlorophenoxy)-4,4-dimethylpentan-3-one in 400 ml of methylene chloride, while stirring and using reflux cooling, and the mixture was stirred at room temperature overnight. It was then distilled under reduced pressure. 93 g (82% of theory) of 1-chloro-2-(2-methyl-4-chlorophenoxy)-4,4-dimethyl-pentan-3-one of boiling point 113°-117°C/0.2 mm were obtained.

1. temperatureusing reflux
2. temperaturecooling
3. stirringthe mixture was stirred at room temperature overnight
4. distillationIt was then distilled under reduced pressure