Hydrochloric Acid → HCID 21520062, compound

Participants

Reaction Steps

To a solution of 5-amino-3-ethylthio-4-phenoxybenzoic acid (1.16 g) in 1 N sodium hydroxide (4 ml), sodium nitrite (0.28 g) is added. The solution is added slowly to a mixture of acetic acid (10 ml) and concentrated hydrochloric acid (10 ml) while stirring and keeping the temperature of 2°-5°C. The resulting diazonium mixture is poured into acetic acid (20 ml), saturated with sulphur dioxide and containing copper chloride (0.2 g CuCl2, 2 H2O). The reaction mixture is allowed to reach room temperature while stirring. After cooling, the precipitated 3-ethylthio-5-chlorosulfonyl-4-phenoxybenzoic acid is collected by filtration, washed with aqueous acetic acid, and dried in vacuo at room temperature.

Provenance & Evidence