Phenyltrimethylammonium bromide dibromide → HCID 21520277, compound

Participants

Reaction Steps

25.1 g of trimethylphenylammonium tribromide were added at 20°-25°C to a stirred solution of 16.4 g of 2-acetyl-7-(1'-acetoxyethyl)benzofuran in 250 ml of dry tetrahydrofuran. The resulting solution was stirred for 6 hours in order to complete the precipitation of trimethylphenylammonium monobromide. The mixture was poured into 1000 ml of water to which sodium chloride was added to saturation. The product was extracted with diethyl ether, the combined diethyl ether extracts were washed with water and with brine and dried over anhydrous sodium sulphate. The sodium sulphate was filtered off and the filtrate evaporated to dryness. The residual solid was crystallized from diethyl ether to give 8.7 g of 7-(1'-acetoxyethyl)-2-bromoacetylbenzofuran in the form of pale yellow crystals of melting point 86°-88°C.

Provenance & Evidence