Dicyclohexylcarbodiimide → 1,2-Dihydro-5,5-dimethyl-8-(3-methyl-2-octyl)-10-[4-(morpholino)butyryloxy]-3H,5H-thiopyrano[2,3-c][1]benzopyran hydrochloride

HRID 1282856Notes

Reaction equation

HRID 1282856 reaction equation
[CH3:1][C:2]1([CH3:26])[C:7]2[S:8][CH2:9][CH2:10][CH2:11][C:6]=2[C:5]2[C:12]([OH:25])=[CH:13][C:14]([CH:16]([CH:18]([CH3:24])[CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH3:17])=[CH:15][C:4]=2[O:3]1.[ClH:27].[O:28]1[CH2:33][CH2:32][N:31]([CH2:34][CH2:35][CH2:36][C:37](O)=[O:38])[CH2:30][CH2:29]1.C1(N=C=NC2CCCCC2)CCCCC1>>[ClH:27].[CH3:26][C:2]1([CH3:1])[C:7]2[S:8][CH2:9][CH2:10][CH2:11][C:6]=2[C:5]2[C:12]([O:25][C:37](=[O:38])[CH2:36][CH2:35][CH2:34][N:31]3[CH2:30][CH2:29][O:28][CH2:33][CH2:32]3)=[CH:13][C:14]([CH:16]([CH:18]([CH3:24])[CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH3:17])=[CH:15][C:4]=2[O:3]1

Participants

4

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 654438-(1,2-Dimethylheptyl)-1,2,3,5-tetrahydro-5,5-dimethylthiopyrano(2,3-c)(1)benzopyran-10-olHCID 127337464-Morpholin-4-Yl-Butyric Acid Hydrochloride

Product 1

HCID 214339131,2-Dihydro-5,5-dimethyl-8-(3-methyl-2-octyl)-10-[4-(morpholino)butyryloxy]-3H,5H-thiopyrano[2,3-c][1]benzopyran hydrochloride

Procedure

The benzopyran of Example 25 is reacted with γ-morpholinobutyric acid, hydrochloride salt and dicyclohexylcarbodiimide according to the method of Example 10 to yield the desired ester.

Sources & evidence

ORD record
ord-c7b8d2c2fbd94a8ebfc1c82b102c4007
Source dataset
uspto-grants-1976_08
Patent number
US03972880

Reaction notes

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