Dicyclohexylcarbodiimide → HCID 21520008, compound

HRID 1282862Notes

Reaction equation

HRID 1282862 reaction equation
[ClH:1].[CH3:2][C:3]([CH3:15])([CH2:7][CH2:8][N:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1)[C:4]([OH:6])=[O:5].[CH3:16][C:17]1([CH3:40])[C:22]2[CH2:23][S:24][CH2:25][C:21]=2[C:20]2[C:26](O)=[CH:27][C:28]([CH:30]([CH:32]([CH3:38])[CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[CH3:31])=[CH:29][C:19]=2[O:18]1.C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)Cl>[ClH:1].[CH3:40][C:17]1([CH3:16])[C:22]2[CH2:23][S:24][CH2:25][C:21]=2[C:20]2[C:26]([O:5][C:4](=[O:6])[C:3]([CH3:15])([CH3:2])[CH2:7][CH2:8][N:9]3[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]3)=[CH:27][C:28]([CH:30]([CH:32]([CH3:38])[CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[CH3:31])=[CH:29][C:19]=2[O:18]1

Participants

5

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 30449214,4-Dimethyl-7-(3-methyloctan-2-yl)-1,4-dihydro-3H-thieno[3,4-c][1]benzopyran-9-olHCID 68119618HCID 68119618, compound

Product 1

HCID 21520008HCID 21520008, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2,2-Dimethyl-4-piperidinobutyric acid hydrochloride is reacted with 1,3-dihydro-4,4-dimethyl-7-(3-methyl-2-octyl)-9-hydroxy-4H-thieno[3,4-c][1]benzopyran in methylene chloride in the presence of dicyclohexylcarbodiimide to produce 1,3-dihydro-4,4-dimethyl-7-(3-methyl-2-octyl)-9[2,2-dimethyl-4-(piperidino)butyryloxy]-4H-thieno[3,4-c][1] benzopyran hydrochloride.

Sources & evidence

ORD record
ord-695f10374d3349e7904868ad945a2630
Source dataset
uspto-grants-1976_08
Patent number
US03972880

Reaction notes

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