Ammonia → HCID 21520439, compound

HRID 1282894Notes

Reaction equation

HRID 1282894 reaction equation
Br[CH:2]([CH:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:9]([F:17])([F:16])[C:8]([F:19])([F:18])[C:7]2[CH:20]=[CH:21][CH:22]=[CH:23][C:6]1=2)[CH2:3][CH3:4].[NH3:24]>>[F:19][C:8]1([F:18])[C:7]2[CH:20]=[CH:21][CH:22]=[CH:23][C:6]=2[CH:5]([CH2:2][CH2:3][CH2:4][NH2:24])[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:9]1([F:17])[F:16]

Participants

3

Reactant 2

HCID 222Ammonia2×HCID 21520448HCID 21520448, compound

Product 1

HCID 21520439HCID 21520439, compound

Procedure

A mixture of 1 gram of 5-(1-bromopropyl)-10,10,11,11-tetrafluoro-5H-dibenzo[a,d]cycloheptene and 20 ml. of liquid ammonia is heated in a sealed tube at 100°C. for 8 hours. After cooling, the ammonia is allowed to evaporate at room temperature and the residual product diluted with ether and the ethereal solution of the product washed with water, dried, and concentrated to leave as a residue 10,11-dihydro-10,10,11,11-tetrafluoro-5H-dibenzo[a,d]cycloheptene-5-propylamine.

Workup

  1. temperatureAfter cooling
  2. customto evaporate at room temperature
  3. additionthe residual product diluted with ether
  4. washthe ethereal solution of the product washed with water
  5. customdried
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-3ab0a4e9879144a7b1a2db5365d147eb
Source dataset
uspto-grants-1976_08
Patent number
US03972936

Reaction notes

Loading…