Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thiomorpholine | HCID 67164 | — |
| Reactant | 6-Chloro-2,3-dihydro-3-hydroxy-2-imino-4-pyrimidinamine | HCID 1551525 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 5185429 | HCID 5185429 | — |
Reaction Steps
A mixture of 16.1 g of 6-amino-4-chloro-1,2-dihydro-2-imino-1-pyrimidinol, 32.1 g of thiomorphline, and 75 ml of dimethyl formamide is heated at 110°C in a nitrogen atmosphere for 17 hours. The solvent is removed under high vacuum. The residue is dissolved in 2 normal hydrochloric acid, and the resulting solution made basic with 5% ammonium hydroxide. There is deposited 13.0 g (57%) of a crystalline solid mp 242°(dec). Recrystallization from methanol-ethanol gives an off-white crystalline solid, mp 246°C(dec).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US03973016 |
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| Source dataset | uspto-grants-1976_08 |
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| ORD ID | ord-5971cbac111a4e01b2a733085311e34e |
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| Source note | uspto-grants-1976_08 |
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