Methanol → HCID 54378725, compound

Participants

Reaction Steps

A mixture consisting of 1.9 g of α-methyl-2-(p-chlorophenyl)-6-quinolineacetic acid, 28 ml of methanol and 28 drops of concentrated sulphuric acid is kept for 2 hours under reflux. Thereafter the reaction mixture is concentrated on a rotary evaporator. The residue is treated with ice, ehter and 50 ml of 0.5 N sodium chloride solution. After thorough shaking, the aqueous phase is separated off and the organic phase is washed with water, dried over sodium sulphate and evaporated. The residue is dissolved in 25 ml of ethyl acetate and treated with petroleum ether until it crystallises. α-Methyl-2-(p-chlorophenyl)-6-quinolineacetic acid methyl ester of melting point 114°-115°C is obtained.

Provenance & Evidence