反应详情

A solution of 2.5 g of crude 2-phenyl-6-quinolineacetaldehyde in 3 ml of ethanol is slowly added dropwise at room temperature to a suspension of 3.4 g of silver nitrate and 1.6 g of sodium hydroxide in 12 ml of water. After completion of the addition, the mixture is stirred for a further 3 hours. Thereafter the suspension is clarified by filtration and the filtrate is washed with ether and adjusted to a pH of 6. The emulsion thereby produced is extracted with ethyl acetate. The ethyl acetate extracts, after drying, evaporation and recrystallisation of the residue from methanol-pentane, yield 2-phenyl-6-quinolineacetic acid of melting point 176°-179°C.

1. additionAfter completion of the addition
2. filtrationThereafter the suspension is clarified by filtration
3. washthe filtrate is washed with ether
4. customThe emulsion thereby produced
5. extractionis extracted with ethyl acetate
6. customafter drying
7. customevaporation and recrystallisation of the residue from methanol-pentane