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HRID1282959

反应详情

EQUATION

反应方程式

HRID 1282959 的结构方程式

REACTANTS

反应物

2
结构：C=[N+]=[N-]
HCID9550

Diazomethane

CH2N2

结构：CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)O.O=C(O)[C@@H]1CCCN1
HCID68146244

未命名化合物

PRODUCTS

生成物

1
结构：CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)OC
HCID68146169

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CC(=O)O
催化剂HCID176

Acetic Acid

C2H4O2

结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

The tripeptide acid of Example 1 (4.6 g) is dissolved in methanol and treated with an ethereal solution of diazomethane until a persistent yellow color is obtained. After 0.5 hour a few drops of acetic acid are added to discharge the yellow color; the solvent is removed in vacuo and replaced with ethyl acetate. This solution is washed sequentially with 0.1 N HCl, water, saturated sodium bicarbonate and water. The organic phase is dried over magnesium sulfate and concentrated to dryness to yield the title compound.

WORKUP

后处理

  1. customis obtained
  2. customthe solvent is removed in vacuo
  3. washThis solution is washed sequentially with 0.1 N HCl, water, saturated sodium bicarbonate and water
  4. dry with materialThe organic phase is dried over magnesium sulfate
  5. concentrationconcentrated to dryness