Hydrochloric Acid → HCID 21519202, compound

Participants

Reaction Steps

A mixture of 2-(N-acetyl-3-methoxyanilino)methylmorpholine oxalate (2 g.) and concentrated hydrochloric acid (25 ml.) is heated under reflux for 24 hours. The solution is cooled, diluted with ice (25 g.) basified with sodium hydroxide solution and then extracted with ether (2 × 100 ml.). The ethereal extract is dried over anhydrous sodium sulphate, filtered and concentrated to about 25 ml. On addition of an ethereal solution of oxalic acid there is obtained 2-(3-methoxyanilino)methylmorpholine oxalate, m.p. 156°-157°C. The corresponding maleate at 145°-147°C. (decomposition).

Provenance & Evidence