Methyl Isocyanate → HCID 152749587, compound

HRID 1283057Notes

Reaction equation

HRID 1283057 reaction equation
[CH3:1][N:2]=[C:3]=[O:4].[CH2:5]([O:7][C:8]([NH:10][C:11]([NH2:13])=[NH:12])=[O:9])[CH3:6]>O1CCOCC1>[CH3:1][NH:2][C:3]([NH:13][C:11]([NH:10][C:8]([O:7][CH2:5][CH3:6])=[O:9])=[NH:12])=[O:4]

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 178473545HCID 178473545, compound

Product 1

HCID 152749587HCID 152749587, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

5.1 parts by weight of methylisocyanate were added to a suspension of 10 parts by weight of ethoxycarbonylguanidine (manufactured according to Isr. J. Chem. 8, 651 [1970] ) in 60 parts by volume of anhydrous dioxane, in the course of which the temperature rose to 45°C and the precipitate dissolved. After a short time, a crystalline precipitate separated out again, which was filtered off after cooling and washed with ether. It was dried in vacuo over P2O5 and paraffin chips.

Workup

  1. customrose to 45°C
  2. dissolutionthe precipitate dissolved
  3. customAfter a short time, a crystalline precipitate separated out again
  4. filtrationwhich was filtered off
  5. temperatureafter cooling
  6. washwashed with ether
  7. dry with materialIt was dried in vacuo over P2O5 and paraffin chips

Sources & evidence

ORD record
ord-077a4abc77884714a6050915fab7b492
Source dataset
uspto-grants-1976_08
Patent number
US03974142

Reaction notes

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