2,3-Dimethylaniline → HCID 53746487, compound

Participants

Reaction Steps

A mixture of 18.3 g. of 2,3,6-trichloropyrimidine, 10.6 g. of sodium carbonate and 12.0 g. of ethyl mercaptoacetate in 250 ml. of ethanol was heated with stirring under reflux for 3 hours. 2,3-Dimethylaniline (12.2 g.) was added and refluxing with stirring was continued overnight. The reaction mixture was filtered and the filtrate taken to dryness on a rotary evaporator. The residual oil was dissolved in 100 ml. of ethyl acetate and the resulting solution was diluted to 250 ml. with petroleum ether. There was obtained 5 g. of product. Recrystallization from heptane gave 3.8 g. of pure product, mp. 114°-116°C.

Provenance & Evidence