反应详情

A mixture of the residual oil [(6-chloro-4-pyrimidinylthio)acetic acid ethyl ester], 5.6 g. of p-chlorobenzylamine and 4.26 g. of sodium carbonate in 150 ml. of ethanol was heated under reflux for 5 hours. The mixture was filtered and was cooled. The precipitate thus formed was collected and recrystallized from ethanol to afford 5.2 g. of product, m.p. 116°-120°C.

1. temperatureunder reflux for 5 hours
2. filtrationThe mixture was filtered
3. temperaturewas cooled
4. customThe precipitate thus formed
5. customwas collected
6. customrecrystallized from ethanol
7. customto afford 5.2 g