Sodium Carbonate → HCID 54541369, compound

HRID 1283087Notes

Reaction equation

HRID 1283087 reaction equation
[CH2:1]([O:3][C:4](=[O:14])[CH2:5][S:6][C:7]1[CH:12]=[C:11](Cl)[N:10]=[CH:9][N:8]=1)[CH3:2].[Cl:15][C:16]1[CH:23]=[CH:22][C:19]([CH2:20][NH2:21])=[CH:18][CH:17]=1.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[CH2:1]([O:3][C:4](=[O:14])[CH2:5][S:6][C:7]1[CH:12]=[C:11]([NH:21][CH2:20][C:19]2[CH:22]=[CH:23][C:16]([Cl:15])=[CH:17][CH:18]=2)[N:10]=[CH:9][N:8]=1)[CH3:2]

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 660364-ChlorobenzylamineHCID 12617581HCID 12617581, compound

Product 1

HCID 54541369HCID 54541369, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of the residual oil [(6-chloro-4-pyrimidinylthio)acetic acid ethyl ester], 5.6 g. of p-chlorobenzylamine and 4.26 g. of sodium carbonate in 150 ml. of ethanol was heated under reflux for 5 hours. The mixture was filtered and was cooled. The precipitate thus formed was collected and recrystallized from ethanol to afford 5.2 g. of product, m.p. 116°-120°C.

Workup

  1. temperatureunder reflux for 5 hours
  2. filtrationThe mixture was filtered
  3. temperaturewas cooled
  4. customThe precipitate thus formed
  5. customwas collected
  6. customrecrystallized from ethanol
  7. customto afford 5.2 g

Sources & evidence

ORD record
ord-0799cbffb6b24542bc76e48ba78b77d1
Source dataset
uspto-grants-1976_08
Patent number
US03974162

Reaction notes

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