Sodium Carbonate → HCID 15506311, compound

HRID 1283089Notes

Reaction equation

HRID 1283089 reaction equation
Cl.[CH2:2]([O:4][C:5](=[O:8])[CH2:6][NH2:7])[CH3:3].C(=O)([O-])[O-].[Na+].[Na+].[Cl:15][C:16]1[N:21]=[C:20](Cl)[CH:19]=[C:18]([Cl:23])[N:17]=1>C(O)C>[CH2:2]([O:4][C:5](=[O:8])[CH2:6][NH:7][C:20]1[CH:19]=[C:18]([Cl:23])[N:17]=[C:16]([Cl:15])[N:21]=1)[CH3:3]

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 773782,4,6-TrichloropyrimidineHCID 2723640Glycine ethyl ester, hydrochloride

Product 1

HCID 15506311HCID 15506311, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a stirred mixture of 27.8 g. (0.2 mole) of glycine ethyl ester hydrochloride and 42.4 g. (0.4 mole) of sodium carbonate in 300 ml. of ethanol was added 36.6 g. (0.2 mole) of 2,4,6-trichloropyrimidine. After stirring at room temperature for 2 hours the mixture was filtered. The filtrate was diluted with 300 ml. of water and the precipitate thus formed was collected, dried, and triturated with 600 ml. of boiling petroleum ether. The insoluble material was filtered off and recrystallized from ethanol-petroleum ether to afford 4.7 g. of product, m.p. 89°-91°C.

Workup

  1. additionTo a stirred mixture of 27.8 g
  2. filtrationwas filtered
  3. additionThe filtrate was diluted with 300 ml
  4. customof water and the precipitate thus formed
  5. customwas collected
  6. customdried
  7. customtriturated with 600 ml
  8. filtrationThe insoluble material was filtered off
  9. customrecrystallized from ethanol-petroleum ether
  10. customto afford 4.7 g

Sources & evidence

ORD record
ord-e00f9b6891fd47229b41656f4bf82d89
Source dataset
uspto-grants-1976_08
Patent number
US03974162

Reaction notes

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