Dimethylformamide → HCID 12274195, compound

Participants

Reaction Steps

A solution of 7.8 g of potassium cyanide in 20 ml of water is added dropwise to a mixture of 23 g of 7-chloromethyl-5H-[1]benzopyrano[2,3-b]-pyridine and 200 ml of dimethylformamide, and the whole mixture is allowed to stand at 55°-60°C for 2 hours. The reaction mixture is poured into a large amount of water, and the crystalline precipitate is filtered off, washed with water and recrystallized from aqueous dioxane to give 20 g of 5H-[1]-benzopyrano[2,3-b]pyridin-7-yl-acetonitrile melting at 166°-167°C.

Provenance & Evidence