Water → HCID 21519234, compound

Participants

Reaction Steps

A solution of 61 grams of 2-(1-hydroxy-2-phenylcyclohexyl)-propionic acid (I) in 200 ml tetrahydrofuran is added dropwise to 30 grams of lithium aluminum hydride in 700 ml ether. After refluxing for 21/2 hours, the mixture is cooled to -5° and treated successively with 140 ml ethyl acetate and 150 ml water. The slurry is filterd, the residue on the filter paper is washed well with ether which is combined wiht the filtrate and the solutin dried over magnesium sulfate. Evaporation of the solution left 57 grams of product (II) melting at 89°-93°C.

Provenance & Evidence