Trimethylamine → HCID 21519236, compound

Participants

Reaction Steps

2-(1-Hydroxy-2-phenylcyclohexyl)propyl p-toluenesulfonate (Example II, Compound III) (10 g) in 75 ml ethanol is stirred at room temperature for 54 hours with 15 ml trimethylamine. The mixture is then heated at 75° for 7 hours in a pressure bottle, concentrated and 125 ml water added. The solution is seeded and the resultant solid filtered and washed to give 6.5 g product, m. 85°-7°.

Provenance & Evidence