反应详情

温度

170 °C

A mixture of 2-aminoquinoline-3-carboxamide (2.0 g., 1.15 millimoles), ethyl oxamate (2.71 g., 23.1 millimoles), ethylene glycol (10 ml.) and sodium methoxide (10 mg.) is heated at 170° C. for 1 hour. The product is precipitated by slow addition of ice cold methanol (50 ml.) to the hot reaction mixture followed by chilling in an ice bath. It is filtered off, washed with cold methanol and dried in vacuo. Yield = 0.768 g. (28%). M.P. 320° C.

1. customThe product is precipitated by slow addition of ice cold methanol (50 ml.) to the hot reaction mixture
2. temperatureby chilling in an ice bath
3. filtrationIt is filtered off
4. washwashed with cold methanol
5. customdried in vacuo