HCID 135705339, compound → HCID 135705338, compound

HRID 1283169Notes

Reaction equation

HRID 1283169 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]1[N:12]=[C:13]([C:17]([O:19]CC)=[O:18])[NH:14][C:15](=[O:16])[C:6]1=[CH:5]2.[OH:22][C:23]1C=C2C(=CC=1)N=C1N=C(C(O)=O)NC(=O)C1=C2>>[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:22][CH3:23])[N:8]=[C:7]1[N:12]=[C:13]([C:17]([OH:19])=[O:18])[NH:14][C:15](=[O:16])[C:6]1=[CH:5]2

Participants

3

Reactant 2

HCID 135705339HCID 135705339, compoundHCID 136209357HCID 136209357, compound

Product 1

HCID 135705338HCID 135705338, compound

Procedure

In like manner, ethyl 7-hydroxypyrimido[4,5-b]quinolin-4(3H)one-2-carboxylate hemitrifluoroacetate (210 mg.) is converted to 7hydroxypyrimido[4,5-b]quinolin-4(3H)one-2-carboxylic acid. Yield - 191 mg., 91%; m.p. 340°C (dec.)

Workup

  1. customYield - 191 mg

Sources & evidence

ORD record
ord-458215a6ed9b4fbcae4f88da201c558f
Source dataset
uspto-grants-1976_08
Patent number
US03974161

Reaction notes

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